Final research plan for breast cancer: screening and how do they use this information in their decisions to undergo screening as reproducibility of measures . Standardizing echocardiography measurements that guide treatment decisions in cancer is needed • the authors assessed the reproducibility of echocardiographic measurements in cancer across two echocardiography core laboratories. Cancer was a fact of life in the village – the assumption was that you get to a certain age, you develop cancer and you die, badly therefore, i was highly motivated to break this vicious cycle however, because my work was quite basic, even though i was working in the pharmaceutical industry, the time-horizon for impact was quite distant. The cancer moonshot needs a reproducibility toolkit in may 2016, iclac wrote a letter to us vice president joe biden and the national cancer advisory board, urging that common principles and requirements are adopted for training and quality assurance testing of research materials.
The scientific community and decision‐makers are increasingly concerned about transparency and reproducibility of epidemiologic studies using longitudinal healthcare databases we explored the extent to which published pharmacoepidemiologic studies using commercially available databases could be reproduced by other investigators. Abstract p2-05-04: evaluation of intra-tumor heterogeneity, test reproducibility and their impact in breast cancer samples assessed by prosigna™: results from a decision impact prospective study and a matched case-control study. Clinical decision-making regarding treatment options in breast cancer often relies on the application of a ki67 cutoff to classify patients into “ki67 high” or “ki67 low” risk groups widely varying cutoff values, however, further impede the clinical utility of ki67 and make it difficult to compare ki67 data across different studies.
Breast cancer is the most common cancer in women and a leading cause of cancer death worldwide management of breast cancer relies on the availability of robust clinical and pathological prognostic and predictive factors to guide patient decision making and the selection of treatment options. One result of this crisis is an increased awareness of reproducibility, and scientific institutions are taking steps to improve it the national institutes of health (nih) is putting several initiatives in place, including training modules and grant application checklists, while scientific journal elife has started the reproducibility project: cancer biology, to independently replicate results . Improving reproducibility if the time from initial submission to first decision after peer review exceeds 60 days, we will provide that author with a full waiver .
Aims to investigate the accuracy and reproducibility of a scoring system for cervical intraepithelial neoplasia (cin1–3) based on immunohistochemical (ihc) biomarkers ki-67 and p16ink4a. Cancer is a complex disease: it also showed greater than 99 percent reproducibility and repeatability keep in mind that because this is an at-home test it is . Reproducibility of echocardiographic techniques for sequential assessment of background decisions regarding cancer therapy are based on temporal changes of ef . Eg breast cancer her2 smith j repeatability and reproducibility of decisions by latent fingerprint examiners we tested latent print examiners on the .
Associations of pathologist characteristics with reproducibility and accuracy fred hutchinson cancer research or in the decision to submit the article for. Dietary factors play a major role in the development of colorectal cancer this study evaluated the reproducibility and validity of a 109-food item food frequency questionnaire (ffq) to measure the consumption of foods and nutrients related to the development of colorectal cancer in a population . Reproducibility of her2/neu scoring in gastric cancer and assessment of the 10% cut-off rule both factors on therapeutic decision, especially if the positive . Consequently, they launched the clinical proteomic tumor analysis consortium (cptac ) in 2006 to address rigor and reproducibility in proteomic technologies cptac is a us effort to accelerate the understanding of the molecular basis of cancer through the application of large-scale proteome and genome analysis.
The reproducibility project: cancer biology is an open investigation of reproducibility in preclinical cancer biology research publication decisions and their . Methods to enhance the reproducibility of decisions using more targeted (eg individual-level) but potentially much noisier subsets cancer genome atlas . Conclusion: we showed a reliability and reproducibility of decision made at mdtm when guidelines are well de- fined the therapeutic attitudes were less reproducible in locally advanced pca but decision concerning those cases.
Overview of the use of oncotype dx ® as an additional treatment decision tool in early breast cancer reproducibility and sources of imprecision were investigated using individual patient . Accurate determination of the predictive markers human epidermal growth factor receptor 2 (her2/erbb2), estrogen receptor (er/esr1), progesterone receptor (pgr/pgr), and marker of proliferation ki67 (mki67) is indispensable for therapeutic decision making in early breast cancer. Improving early detection to reduce the burden of cancer enable better treatment decisions, and improve cancer prevention and reproducibility of biomarker .